P54: Anti-Apoptotic Effect of Neural Regeneration Peptides (NRP) 2945 on Pentylenetetrazole-Induced Seizures in Rats
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p54: anti-apoptotic effect of neural regeneration peptides (nrp) 2945 on pentylenetetrazole-induced seizures in rats
delayed neuronal death after seizure attack may be mediated by the induction of apoptosis-pathway. caspase-3, a mammalian cysteine protease, promotes apoptosis after some neurological disorders. neuron regeneration peptides (nrps) are small synthetic peptides that stimulate neural proliferation, migration, and differentiation with no apparent toxicity and high target specificity in cns. in the ...
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Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current AEDs therapy. Some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the p...
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OBJECTIVE The aim of the study to elicit effects of pure quercetin in pentylenetetrazole (PTZ) and picrotoxin induced seizures. MATERIALS AND METHODS Each animal group was divided into six groups and composed of six rats. Rats were assigned to the following experiments and groups (G): (G1) PTZ 45 mg/kg + DMSO; (G2) PTZ 45 mg/kg + 5 mg/kg quercetin; (G3) PTZ 45 mg/kg + 10 mg/kg quercetin; (G4)...
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Cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. Thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. In the present study, the effect of Khamira Marwarid (KAH 1 ), a formulation based on Indian system of Unani medicine, was evaluated on the course of pentylenetetrazole...
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Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex. Cortical norepinephrine then increases GABAergic transmission and increases seizure threshold. Another approach, responsive nervous stimulation...
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عنوان ژورنال
دوره 2 شماره 4
صفحات 104- 104
تاریخ انتشار 2014-12
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